The book entitled: "Comprehensive Toxicology : Toxicology of the Respiratory System" is in the Toxicology Books section of Pharmacology, Pharmaceutical Science and Toxicology Books area...

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DESCRIPTION: Volume 8 begins with a detailed description of the functional anatomy of the various regions and critical cells of the respiratory tract, from the nasal cavity to the gas exchange region. This section conveys the structural heterogeneity of the respiratory system and how it determines tissue and cellular targets for toxic agents. The next section describes functional and biochemical responses of the lungs to toxic insult and includes chapters on carcinogenic and developmental responses to chemical exposure. The final section comprises over 20 chapters describing injurious effects of selected chemicals of toxicologic interest. Human health concerns as well as mechanisms of toxicity are emphasized. Unlike other volumes that have treated this subject, attention is devoted to effects of toxic agents on both the airways and the pulmonary vasculature.

TABLE OF CONTENTS: Introduction (R.A. Roth). Nasal airways (J.R. Harkema). Tracheobronchial airways (K.E. Pinkerton, K.P. Avadhanam, J.L. Peake, C.G. Plopper). Pulmonary blood vessels (ie. conducting vessels only) (N.F. Voelkel, R.M. Tuder). Alveolar epithelium in lung toxicology (L.-Y. Chang, J.D. Crapo). Vascular endothelium and the lungs (M.J. Block, E.A. Drab, D.B. Rubin). The air/blood interface: connective tissue and interstitium (S.N. Giri, Q. Wang). Inflammatory cells of the lung: macrophages (A. Holian). Inflammatory cells of the lung: polymorphonuclear leukocytes (D.M. Hyde, A. Sterner-Kock). Pulmonary mechanical function and gas exchange (D.L. Costa, J.S. Tepper). Biochemical function of lungs: clearance of circulating, endogenous agents (I.G. Horvath E. Tzoufi, J.D. Catravas). Biochemical function of lungs: metabolism of xenobiotic agents (A.R. Buckpitt, M.K. Cruikshank). Carcinogenic responses of the respiratory tract (F.F. Hahn). Pulmonary developmental responses to toxicants (M. Voit Fanucchi, C.G. Plopper). Mucus and surfactant (T. Honda, K. Kubo, T. Kobayashi). Cell damage and cell renewal in the lung (H.P. Witschi). In vitro systems for studying respiratory system toxicology (E.M. Postlethwait, A. Bidani). Ozone (L. van Bree, J.A. Last). Oxygen toxicity (L. Frank). Oxides of nitrogen (M.J. Utell, M.W. Frampton). Sulfur oxides (R.B. Schlesinger, I. Jaspers). Aldehydes (H. d'A. Heck). Coal dust (V. Castranova, B.S. Ducatman). Crystalline silica and silicosis (K.E. Driscoll, G.D. Guthrie). Asbestos (A.R. Brody). Organic dusts (R.C. Rylander). Etiology of occupational asthma (TDI, plastic monomers, red cedar, etc.) (L. Fabbri, G. Caramori, P. Maestrelli). Carcinogenic effects of cigarette smoke on the respiratory tract (S.S. Hecht). Noncarcinogenic effects of cigarette smoke on the respiratory tract (T.J. Gronski Jr, S.D. Shapiro). Radon (J.M. Samet). Toxicity of airborne metals (D.E. Gardner, J.A. Graham). Nuisance dusts (R.O. McClellan). The pulmonary toxicity of chemotherapeutic agents (K. Ramu, J.P. Kehrer). Bleomycin-induced pulmonary fibrosis (D. G. Hoyt, J.S. Lazo). Cationic, amphiphilic drugs (M.J. Reasor). Pyrrolizidine alkaloids (C.M. Hoorn). Paraquat (L.L. Smith). Selected, nontherapeutic agents (3MI, ANTU, 2-naphthol, 3MF, 4IP, etc.) (G.S. Yost). Bacterial endotoxin (R. Burrell).

AUTHORS: Sipes, I.G.;McQueen, C.A.;Gandolfi, A.J.;Roth, R.A.

PAGES: 657 pages

PUBLISH DATE: 01/07/1997

ISBN Number: 0-08-042973-4

USA Book Price: $181.95
UK Book Price: £121

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