DESCRIPTION: What are the consequences, if any, of repeated brief seizures that are the defining feature of epilepsy? A firm answer to this question has been surprisingly elusive for a variety of reasons. Clearly there is a subset of patients who appear to tolerate seizures with relatively limited long-term consequences, and not all patients are destined to progress to intractability with frequent seizures and disability. This variability and individual susceptibility has made it difficult to make statements that fairly apply to the full range of people with epileptic disorders, whose disorders span a broad spectrum from mild with excellent control and few limitations, to severe with multiple daily seizures and pronounced disability that affects employment, educational performance, an personal life.
This volume seeks to explore the spectrum of severe to more subtle damage that may be a consequence of seizures. The contributing authors have addressed

TABLE OF CONTENTS: List of contributors.
Preface.
Acknowledgements.
Section I. Seizure-induced damage in experimental epilepsy.
1. Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives (B.S. Meldrum).
2. Are seizures harmful: What can we learn from animal models?
(A.J. Cole, S. Koh, Y. Zheng).
3. Doubt and certainty in counting (R.W. Guillery, B.K. August).
4. Design based stereological methods for counting neurons
(M.J. West ).
5. The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus
(F.E. Dudek et al.).
6. Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy (A. Pitkänen et al.).
7. Does convulsive status epilepticus (SE) result in cerebral damage or affect the course of epilepsy - the epidemiological and clinical evidence? (S. Shorvon).
8. Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits (R. Kotloski et al.).
9. Neuronal apoptosis after brief and prolonged seizures
(J. Bengzon, et al.).
10. Seizure-induced neurogenesis: are more new neurons good for an adult brain? (J.M. Parent, D.H. Lowenstein).
11. Summary. Seizure-induced damage in experimental models
(T. Sutula, A. Pitkänen).
Section II. Mechanisms of seizure-induced damage.
12. Complications associated with genetic background effects in models of experimental epilepsy (P.E. Schauwecker).
13. Genomics and neurological phenotypes: applications for seizure-induced damage (J.A. Del Rio, C. Barlow).
14. Functional genomics in experimental and human temporal lobe epilepsy: powerful new tools to identify molecular disease mechanisms of hippocampal damage (A.J. Becker, O.D. Wiestler, I. Blümcke).
15. What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis (N.G. Bazan, B. Tu, E.B. Rodriguez de Turco).
16. The role of mitochondria and oxidative stress in neuronal damage after brief and prolonged seizures (H.R. Cock).
17. Cell death and metabolic activity during epileptiform discharges and status epilepticus in the hippocampus (U. Heinemann et al.).
18. Summary. Mechanisms of seizure-induced damage (T. Sutula, A. Pitkänen).
Section III. Evidence for seizure-induced damage in human studies: epidemiology, pathology, imaging and clinical studies.
19. Do seizures beget seizures? (W. A. Hauser, J.R. Lee).
20. Do occasional brief seizures cause detectable clinical consequences? (S. Shinnar, W.A. Hauser).
21. Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited (G.W. Mathern et al.).
22. MRI studies. Do seizures damage the brain? (J.S. Duncan).
23. Do prolonged febrile seizures produce medical temporal sclerosis? Hypotheses, MRI evidence and unanswered questions
(D.V. Lewis et al.).
24. Do recurrent seizures cause neuronal damage? A series of studies with MRI volumetry in adult with partial epilepsy
(R. Kälviäinen, T. Salmenperä).
25. Proton magnetic resonance spectroscopic imaging suggests progressive neuronal damage in human temporal lobe epilepsy
(A. Bernasconi et al.).
26. Neuroimaging and the progression of epilepsy (W.H. Theodore, W.D. Gaillard).
27. Summary. Evidence for seizure-induced damage in human studies: epidemiology, pathology, imaging and clinical studies
(T. Sutula, A. Pitkänen).
Section IV. Seizure-induced cell death in development and functional consequences.
28. Seizure-induced damage in the developing human relevance of experimental models (G.L. Holmes, R. Khazipov, Y. Ben-Ari).
29. Seizure-induced neuronal death in the immature brain
(C.G. Wasterlain et al.).
30. Effects of brief seizures during development (L. Velišek, S.L. Moshé).
31. Is neuronal death required for seizure-induced epileptogenesis in the immature brain? (T.Z. Baram, M. Eghbal-Ahmadi, R.A. Bender).
32. Assessing the behavioral and cognitive effects of seizures ion the developing brain (C.E. Stafstrom).
33. Recent experimental studies of the effects of seizures on brain development (J.W. Swann).
34. Summary. Seizure-induced damage in development and functional consequences (T. Sutula, A. Pitkänen).
Section V. Neuropsychological consequences of human epilepsy.
35. Progressive cognitive decline in adolescents and adults with epilepsy (C.B. Dodrill).
36. Progressive cognitive decline in epilepsy. An indication of ongoing plasticity (H. Stefan, E. Pauli).
37. Progressive behavioral changes in children with epilepsy
(J.K. Austin, D.W. Dunn).
38. The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function and the risk of progressive cognitive effects (B.P. Hermann, M. Seidenberg, B. Bell).
39. Effects of chronic epilepsy on declarative memory systems
(C. Helmstaedter).
40. Effects of chronic epilepsy on intellectual functions
(H. Jokeit, A. Ebner).
41. Summary. Neuropsychological consequences of human epilepsy
(T. Sutula, A. Pitkänen)
Section VI. Implications for management.
42. Will brain damage after status epilepticus be history in 2010? (D.M. Treiman).
43. Is complete seizure control imperative? (F. Andermann).
44. Implications for neuroprotective treatments (B.S. Meldrum).
45. Development of neuroprotective compounds in the pharmaceutical industry: where are we, and where are we going
(N. Santilli).
46. So what can be conclude - do seizures damage the brain?
(J. Engel Jr.).
47. Summary. Implications for Management (T. Sutula, A. Pitkänen).
Subject Index.

AUTHORS: Sutula, T.;Pitkanen, A.

PAGES: 544 pages

PUBLISH DATE: 01/05/2002

ISBN Number: 0-444-508-147

USA Book Price: $225.95
UK Book Price: £151

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