DESCRIPTION: An accompanying volume (Volume 6) in this series presents strategies of cellular invasion from the viewpoint of the microbe.
This filed of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research, and brings together cell biologists, microbiologists and immunologists with disparate interests. However, there is a certain unity, even repetition of key themes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular paratism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage, and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cel

TABLE OF CONTENTS: Contents. List of Contributors. Introduction to the Series. Preface (S. Gordon). Secton I Context. The early History of Phagocytosis (T.P. Stossel). Drosophila Hemocytes, Phagocytosis, and Croquemort, a Macrophage Receptor (N.C. Franc). Phagocytosis by Nonprofessional Phagocytes (D. Williams-Herman and Z. Werb). Section II Receptors. Scavenger Receptors and Phagocytosis of Bacteria and Apoptotic Cells (N. Platt, R. Haworth, R.P. da Silva, and S. Gordon). Mannose Receptor and Phagocytosis (I.P. Fraser, R. Alan and B. Ezekowitz). Integrin Receptors of Phagocytes (S.D. Blystone and E.J. Brown). Fc Receptor-Mediated Phagocytosis (S. Greenberg). Section III Signaling. Heterogeneity in Macrophage Phagocytosis (A. Aderem and D.M. Underhill). Signaling through RHO GTPases in Phagocytes (A.E. Abo). Regulatory Roles of Phosphatidylinositol (4,5) Bisphosphate in Cell Signalin, Membrane Traffic, and the Cytoskeleton (S. Cockcroft). Section IV The Pathway. Pathways through the Macrophage Vacuolar Compartment (J.A. Swanson). Sequential Maturation of Phagosomes provides unique Targets for Pathogens (C. Alvarez-Dominguez, L. Mayorga, and P.D. Stahl). Phagosomal Acidification: Mechanisms and Funtional Significance (D.J. Hackam, O.
D. Rotstein, and S. Grinstein). The Phagocyte Actin Cytoskeleton (H. Sun, K. Lin, M. Yamamoto, and H.L. Yin). Section V Responses. Nramp1: A Novel Macrophage Protein with a Key Function in Resistance to Intracellular Pathogens (S. Gruenheid, E. Skamene, and P. Gros). Uptake and Presentation of Phagocytosed Antigens by Dendritic Cells (M.L. Albert, S. Turley, W. Garrett, I. Mellman, K. Inaba, N. Bhardway, and R.M. Steinman). Processing and Presentation of Phagocytosed Antigens to the Immune System (J. Pieters). Antimicrobial Mechanisms of Macrophages (M.U. Shiloh and C.F. Nathan). Components and Organization of the Nadph Oxidase of Phagocytic Cells: Its Role in Microbial Killing and in the Molecular Pathology of Chronic Granulomatous Disease (A.W. Segal, f. wientjes, R.W. Stockley, and L.V. Dekker). Oxygen-Independent Antimicrobial Mechanisms of PMN (P. Elsbach). Index.

AUTHORS: Gordon, S.

PAGES: 536 pages

PUBLISH DATE: 01/12/1999

ISBN Number: 1-55938-999-0

USA Book Price: $104.95
UK Book Price: £69.95

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